An antipathogenic compound that targets the OxyR peroxide sensor in Pseudomonas aeruginosa.

ABSTRACT: Introduction. Antipathogenic or antivirulence strategy is to target a virulence pathway that is dispensable for growth, in the hope to mitigate the selection for drug resistance.Hypothesis/Gap Statment. Peroxide stress responses are one of the conserved virulence pathways in bacterial pathogens and thus good targets for antipathogenic strategy.Aim. This study aims to identify a new chemical compound that targets OxyR, the peroxide sensor required for the full virulence of the opportunistic human pathogen, Pseudomonas aeruginosa.Methodology. Computer-based virtual screening under consideration of the 'eNTRy' rules and molecular docking were conducted on the reduced form of the OxyR regulatory domain (RD). Selected hits were validated by their ability to ph

SUBMITTER: Oh HY 

PROVIDER: S-EPMC8289212 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature