(Macro)Molecular Imprinting of Proteins on PCL Electrospun Scaffolds.

ABSTRACT: Biological recognition sites are very useful for biomedical purposes and, more specifically, for polymeric scaffolds. However, synthetic polymers are not capable of providing specific biological recognition sites. To solve this inconvenience, functionalization of biological moieties is typically performed, oftentimes via peptide binding. In this sense, the main task is capturing the biological complexity of a protein. This study proposes a possible alternative solution to this challenge. Our approach is based on the combination of molecular imprinting (MI) and electrospinning processes. We propose here an alternative MI approach with polymeric structures, instead of using cross-linkers and monomers as conventionally performed. Different PCL-protein scaffolds were produced via electrospinni

SUBMITTER: Perez-Puyana V 

PROVIDER: S-EPMC8289240 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature