Nitroxides as Building Blocks for Nanoantioxidants.

ABSTRACT: Nitroxides are an important class of radical trapping antioxidants whose promising biological activities are connected to their ability to scavenge peroxyl (ROO^•) radicals. We have measured the rate constants of the reaction with ROO^• (k_inh) for a series of 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) derivatives as 5.1 × 10⁶, 1.1 × 10⁶, 5.4 × 10⁵, 3.7 × 10⁵, 1.1 × 10⁵, 1.9 × 10⁵, and 5.6 × 10⁴ M^-1 s^-1 for -H, -OH, -NH₂, -COOH, -NHCOCH₃, -CONH(CH₂)₃CH₃, and ═O substituents in the 4 position, with a good Marcus relationship between log (k_inh) and E° for the R₂NO

SUBMITTER: Genovese D 

PROVIDER: S-EPMC8289242 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature