Thalamus Radiomics-Based Disease Identification and Prediction of Early Treatment Response for Schizophrenia.

ABSTRACT:

Background

Emerging evidence suggests structural and functional disruptions of the thalamus in schizophrenia, but whether thalamus abnormalities are able to be used for disease identification and prediction of early treatment response in schizophrenia remains to be determined. This study aims at developing and validating a method of disease identification and prediction of treatment response by multi-dimensional thalamic features derived from magnetic resonance imaging in schizophrenia patients using radiomics approaches.

Methods

A total of 390 subjects, including patients with schizophrenia and healthy controls, participated in this study, among which 109 out of 191 patients had clinical characteristics of early outcome (61 responders and 48 non-responders). Thalamus-based

SUBMITTER: Cui LB 

PROVIDER: S-EPMC8289251 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature