Evaluation of interim MRI changes during limited-field radiation therapy for glioblastoma and implications for treatment planning.

ABSTRACT:

Background and purpose

Consensus for defining gross tumor volume (GTV) and clinical target volume (CTV) for limited-field radiation therapy (LFRT) of GBM are not well established. We leveraged a department MRI simulator to image patients before and during LFRT to address these questions.

Materials and methods

Supratentorial GBM patients receiving LFRT (46 Gy + boost to 60 Gy) underwent baseline MRI (MRI1) and interim MRI during RT (MRI2). GTV1 was defined as T1 enhancement + surgical cavity on MRI1 without routine inclusion of T2 abnormality (unless tumor did not enhance). The initial CTV margin was 15 mm from GTV1, and the boost CTV margin was 5-7 mm. The GTV1 characteristics were categorized into three groups: identical T1 and T2 abnormality (Group A), T1 only with larger

SUBMITTER: Hassanzadeh C 

PROVIDER: S-EPMC8289483 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature