ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension.

ABSTRACT:

Background

Metabolic alterations provide substrates that influence chromatin structure to regulate gene expression that determines cell function in health and disease. Heightened proliferation of smooth muscle cells (SMC) leading to the formation of a neointima is a feature of pulmonary arterial hypertension (PAH) and systemic vascular disease. Increased glycolysis is linked to the proliferative phenotype of these SMC.

Methods

RNA sequencing was applied to pulmonary arterial SMC (PASMC) from PAH patients with and without a BMPR2 (bone morphogenetic receptor 2) mutation versus control PASMC to uncover genes required for their heightened proliferation and glycolytic metabolism. Assessment of differentially expressed genes established metabolism as a major pathway, and the most

SUBMITTER: Li D 

PROVIDER: S-EPMC8289565 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature