Association of Microbial Dysbiosis with Gallbladder Diseases Identified by Bile Microbiome Profiling.

ABSTRACT:

Background

Cholecystitis is an important risk factor for gallbladder cancer, but the bile microbiome and its association with gallbladder disease has not been investigated fully. We aimed to analyze the bile microbiome in normal conditions, chronic cholecystitis, and gallbladder cancer, and to identify candidate bacteria that play an important role in gallbladder carcinogenesis.

Methods

We performed metagenome sequencing on bile samples of 10 healthy individuals, 10 patients with chronic cholecystitis, and 5 patients with gallbladder cancer, and compared the clinical, radiological, and pathological characteristics of the participants.

Results

No significant bacterial signal was identified in the normal bile. The predominant dysbiotic bacteria in both chronic cholecyst

SUBMITTER: Choi SJ 

PROVIDER: S-EPMC8289718 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature