Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data.

ABSTRACT: As the capacity for generating large-scale molecular profiling data continues to grow, the ability to extract meaningful biological knowledge from it remains a limitation. Here, we describe the development of a new fixed repertoire of transcriptional modules, BloodGen3, that is designed to serve as a stable reusable framework for the analysis and interpretation of blood transcriptome data. The construction of this repertoire is based on co-clustering patterns observed across sixteen immunological and physiological states encompassing 985 blood transcriptome profiles. Interpretation is supported by customized resources, including module-level analysis workflows, fingerprint grid plot visualizations, interactive web applications and an extensive annotation framework comprising functional pro

SUBMITTER: Altman MC 

PROVIDER: S-EPMC8289976 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature