Pivotal factors associated with the immunosuppressive tumor microenvironment and melanoma metastasis.

ABSTRACT:

Background

Considering melanoma is the deadliest malignancy among dermatoma and presently lacks effective therapies, there is an urgent need to investigate the potential mechanisms underlying melanoma metastasis and determine prospective therapeutic targets for precise treatment of melanoma.

Method

Hub genes in melanoma metastasis were identified by analyzing RNA-seq data (mRNA, miRNA, and lncRNA) obtained from TCGA database. Then the identified hub genes were validated in human tissues with qRT-PCR, followed by survival analysis. Competing endogenous RNAs of the hub genes were defined to clarify potential molecular mechanism of melanoma progression. Then central gene-related signaling pathways were analyzed, followed by immune cell abundance analysis in tumor microenvironme

SUBMITTER: Zhang C 

PROVIDER: S-EPMC8290234 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature