The genomic landscape of teenage and young adult T-cell acute lymphoblastic leukemia.

ABSTRACT:

Background

Treatment on risk adapted intensive pediatric protocols has improved outcome for teenagers and young adults (TYA) with T-cell acute lymphoblastic leukemia (T-ALL). Understanding the biology of disease in this age group and the genetic basis of relapse is a key goal as patients with relapsed/refractory disease have poor outcomes with conventional chemotherapy and novel molecular targets are required. This study examines the question of whether TYA T-ALL has a specific biological-molecular profile distinct from pediatric or adult T-ALL.

Methods

Genomic characterization was undertaken of a retrospective discovery cohort of 80 patients aged 15-26 years with primary or relapsed T-ALL, using a combination of Genome-Wide Human SNP Array 6.0, targeted gene mutation and pr

SUBMITTER: Mansur MB 

PROVIDER: S-EPMC8290240 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature