Association of Elevated Maternal Serum Total Bile Acids With Low Birth Weight and Intrauterine Fetal Growth Restriction.

ABSTRACT:

Importance

Bile acids play essential roles in metabolic modulation. Excessive serum total bile acid (sTBA) levels during pregnancy are associated with adverse perinatal outcomes; however, their association with the risk of intrauterine growth restriction (IUGR) remains unclear.

Objective

To investigate the association between maternal sTBA concentration during pregnancy and the risk of IUGR.

Design, setting, and participants

This retrospective cohort study included pregnant individuals who delivered live singleton neonates and had regular antenatal examination records available at a hospital-based center in Shanghai, China, from 2014 to 2018. Data were analyzed from July to November 2020.

Exposures

Maternal sTBA concentration during pregnancy.

Main outcomes

SUBMITTER: Song F 

PROVIDER: S-EPMC8290304 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature