Coffee Consumption and Incident Tachyarrhythmias: Reported Behavior, Mendelian Randomization, and Their Interactions.

ABSTRACT:

Importance

The notion that caffeine increases the risk of cardiac arrhythmias is common. However, evidence that the consumption of caffeinated products increases the risk of arrhythmias remains poorly substantiated.

Objective

To assess the association between consumption of common caffeinated products and the risk of arrhythmias.

Design, setting, and participants

This prospective cohort study analyzed longitudinal data from the UK Biobank between January 1, 2006, and December 31, 2018. After exclusion criteria were applied, 386 258 individuals were available for analyses.

Exposures

Daily coffee intake and genetic polymorphisms that affect caffeine metabolism.

Main outcomes and measures

Any cardiac arrhythmia, including atrial fibrillation or flutter, sup

SUBMITTER: Kim EJ 

PROVIDER: S-EPMC8290332 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature