The utility of ⁶⁸Gallium-DOTATATE PET/CT in the detection of von Hippel-Lindau disease associated tumors.

ABSTRACT:

Purpose

Patients with von Hippel-Lindau (VHL) disease may develop various tumors, including neuroendocrine tumors of the pancreas (PNETs) and adrenal, central nervous system and retinal hemangioblastomas, kidney tumors and more. ⁶⁸Ga-DOTATATE positron emission tomography (PET)/computerized tomography (CT) has been shown to be highly accurate for tumors with cells expressing somatostatin receptors. We aimed to assess the performance of ⁶⁸Ga-DOTATATE PET/CT in patients with VHL disease.

Methods

Patients with a diagnosis of VHL were enrolled in a prospective study and underwent surveillance imaging for pancreatic lesions (n = 301). The current analysis includes 73 evaluations with multiple imaging modalities of 36 patients (2.1 ± 0.8 evaluations/patient, r

SUBMITTER: Shell J 

PROVIDER: S-EPMC8290514 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature