Health-related quality of life in amyotrophic lateral sclerosis using EQ-5D-5L.

ABSTRACT:

Background

The study aimed to appraise the health-related quality of life (HRQoL) measured by the five-level EuroQol-5 dimensions (EQ-5D-5L) in amyotrophic lateral sclerosis (ALS), and to explore the associations between non-motor symptoms (mood changes, cognitive disturbances and sleep disturbances).

Methods

EQ-5D-5L descriptive scores were converted into a single aggregated "health utility" score. A calibrated visual analog scale (EQ-VAS) was used for self-rating of current health status. Multiple logistic regression analysis was used to explore the factors associated with HRQoL.

Results

Among the 547 enrolled ALS patients who were assessed using EQ-5D-5L, the highest frequency of reported problems was with usual activities (76.7%), followed by self-care (68.8%) and

SUBMITTER: Wei QQ 

PROVIDER: S-EPMC8290546 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature