Microglial responses to CSF1 overexpression do not promote the expansion of other glial lineages.

ABSTRACT:

Background

Colony-stimulating factor 1 (CSF1) expression in the central nervous system (CNS) increases in response to a variety of stimuli, and CSF1 is overexpressed in many CNS diseases. In young adult mice, we previously showed that CSF1 overexpression in the CNS caused the proliferation of IBA1⁺ microglia without promoting the expression of M2 polarization markers.

Methods

Immunohistochemical and molecular analyses were performed to further examine the impact of CSF1 overexpression on glia in both young and aged mice.

Results

As CSF1 overexpressing mice age, IBA1⁺ cell numbers are constrained by a decline in proliferation rate. Compared to controls, there were no differences in expression of the M2 markers ARG1 and MRC1 (CD206) in CSF1 overexp

SUBMITTER: De I 

PROVIDER: S-EPMC8290555 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature