Investigating causal relationships between exposome and human longevity: a Mendelian randomization analysis.

ABSTRACT:

Background

Environmental factors are associated with human longevity, but their specificity and causality remain mostly unclear. By integrating the innovative "exposome" concept developed in the field of environmental epidemiology, this study aims to determine the components of exposome causally linked to longevity using Mendelian randomization (MR) approach.

Methods

A total of 4587 environmental exposures extracting from 361,194 individuals from the UK biobank, in exogenous and endogenous domains of exposome were assessed. We examined the relationship between each environmental factor and two longevity outcomes (i.e., surviving to the 90th or 99th percentile age) from various cohorts of European ancestry. Significant results after false discovery rates correction underwent

SUBMITTER: Huang SY 

PROVIDER: S-EPMC8290559 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature