Comparative and functional genomics of the ABC transporter superfamily across arthropods.

ABSTRACT:

Background

The ATP-binding cassette (ABC) transporter superfamily is comprised predominantly of proteins which directly utilize energy from ATP to move molecules across the plasma membrane. Although they have been the subject of frequent investigation across many taxa, arthropod ABCs have been less well studied. While the manual annotation of ABC transporters has been performed in many arthropods, there has so far been no systematic comparison of the superfamily within this order using the increasing number of sequenced genomes. Furthermore, functional work on these genes is limited.

Results

Here, we developed a standardized pipeline to annotate ABCs from predicted proteomes and used it to perform comparative genomics on ABC families across arthropod lineages. Using Kruskal-

SUBMITTER: Denecke S 

PROVIDER: S-EPMC8290562 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature