Role of α- and β-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease.

ABSTRACT: The urinary tract is highly innervated by autonomic nerves which are essential in urinary tract development, the production of growth factors, and the control of homeostasis. These neural signals may become dysregulated in several genitourinary (GU) disease states, both benign and malignant. Accordingly, the autonomic nervous system is a therapeutic target for several genitourinary pathologies including cancer, voiding dysfunction, and obstructing nephrolithiasis. Adrenergic receptors (adrenoceptors) are G-Protein coupled-receptors that are distributed throughout the body. The major function of α1-adrenoceptors is signaling smooth muscle contractions through GPCR and intracellular calcium influx. Pharmacologic intervention of α-and β-adrenoceptors is routinely and successfully implemented

SUBMITTER: Archer M 

PROVIDER: S-EPMC8290582 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature