Ferroptosis-related gene signature predicts the prognosis in Oral squamous cell carcinoma patients.

ABSTRACT:

Background

The prognosis of oral squamous cell carcinoma (OSCC) patients is difficult to predict or describe due to its high-level heterogeneity and complex aetiologic factors. Ferroptosis is a novel form of iron-dependent cell death that is closely related to tumour growth and progression. This study aims to clarify the predictive value of ferroptosis-related genes (FRGs) on the overall survival(OS) of OSCC patients.

Methods

The mRNA expression profile of FRGs and clinical information of patients with OSCC were collected from the TCGA database. Candidate differentially expressed ferroptosis-related genes (DE-FRGs) were identified by analysing differences between OSCC and adjacent normal tissues. A gene signature of prognosis-related DE-FRGs was established by univariate Cox

SUBMITTER: Li H 

PROVIDER: S-EPMC8290602 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature