Correlation between vascular endothelial growth factor pathway and immune microenvironment in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Immunotherapy is a crucial therapeutic approach in oncology. However, most patients with head and neck squamous cell carcinoma (HNSCC) do not derive benefit from immunotherapy. Vascular endothelial growth factor (VEGF)/VEGF Receptor 2 (VEGFR2) signaling pathway is one of the most important pathways regulating angiogenesis in tumor. The combination of immunotherapy and anti-angiogenic therapy is considered to improve efficacy of immunotherapy. The correlation between VEGF signaling pathway and tumor immune microenvironment in HNSCC patients is unclear.

Methods

We utilized RNA sequencing and clinical data of HNSCC patients from the TCGA database to study the correlation between VEGF signaling pathway and tumor immune microenvironment, on aspect of immune cell infilt

SUBMITTER: Zhu C 

PROVIDER: S-EPMC8290614 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature