A systems-biology clinical trial of a personalized multimodal lifestyle intervention for early Alzheimer's disease.

ABSTRACT:

Introduction

There is an urgent need to develop effective interventional treatments for people with Alzheimer's disease (AD). AD results from a complex multi-decade interplay of multiple interacting dysfunctional biological systems that have not yet been fully elucidated. Epidemiological studies have linked several modifiable lifestyle factors with increased incidence for AD. Because monotherapies have failed to prevent or ameliorate AD, interventional studies should deploy multiple, targeted interventions that address the dysfunctional systems that give rise to AD.

Methods

This randomized controlled trial (RCT) will examine the efficacy of a 12-month personalized, multimodal, lifestyle intervention in 60 mild cognitive impairment (MCI) and early stage AD patients (aged 50+,

SUBMITTER: McEwen SC 

PROVIDER: S-EPMC8290633 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature