Epigenetic Effects Promoted by Neonicotinoid Thiacloprid Exposure.

ABSTRACT:

Background

Neonicotinoids, a widely used class of insecticide, have attracted much attention because of their widespread use that has resulted in the decline of the bee population. Accumulating evidence suggests potential animal and human exposure to neonicotinoids, which is a cause of public concern.

Objectives

In this study, we examined the effects of a neonicotinoid, thiacloprid (thia), on the male reproductive system.

Methods

The pregnant outbred Swiss female mice were exposed to thia at embryonic days E6.5 to E15.5 using "0," "0.06," "0.6," and "6" mg/kg/day doses. Adult male progeny was analyzed for morphological and cytological defects in the testes using hematoxylin and eosin (H&E) staining. We also used immunofluorescence, Western blotting, RT-q

SUBMITTER: Hartman C 

PROVIDER: S-EPMC8290843 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature