Exposure to the Gram-Negative Bacteria Pseudomonas aeruginosa Influences the Lung Dendritic Cell Population Signature by Interfering With CD103 Expression.

ABSTRACT: Lung dendritic cells (DCs) are divided into two major populations, which include CD103⁺XCR1⁺ cDC1s and CD11b⁺Sirpα⁺ cDC2s. The maintenance of their relative proportions is dynamic and lung inflammation, such as caused by exposure to lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, can have a significant impact on the local cDC signature. Alterations in the lung cDC signature could modify the capacity of the immune system to respond to various pathogens. We consequently aimed to assess the impact of the Gram-negative bacteria Pseudomonas aeruginosa on lung cDC1 and cDC2 populations, and to identify the mechanisms leading to alterations in cDC populations. We observed that exposure to P. aeruginosa

SUBMITTER: Brassard J 

PROVIDER: S-EPMC8291145 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature