Association between ALDH2 and ADH1B Polymorphisms and the Risk for Colorectal Cancer in Koreans.

ABSTRACT:

Purpose

Excessive alcohol consumption has been linked to an increased risk of colorectal cancer (CRC). We evaluated the association between alcohol-related genetic variants and CRC risk.

Materials and methods

The study cohort consisted of 5,435 CRC cases and 3,553 population-based cancer-free controls. Genotype data were generated from germline DNA using the Infinium OncoArray-500K BeadChip in 2,535 cases and 2,287 controls and the Infinium Multi-Ethnic Global BeadChip in 2,900 cases and 1,266 controls. The associations between aldehyde dehydrogenase 2 (ALDH2) rs671 and alcohol dehydrogenase 1B (ADH1B) rs1229984 polymorphisms and CRC risk were assessed using multivariate logistic regression analyses.

Results

Compared with the major homozygous ALDH2 genotype (GG), hete

SUBMITTER: Choi CK 

PROVIDER: S-EPMC8291179 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature