Optical Gap Biomarker in Cone-Dominant Retinal Dystrophy.

ABSTRACT:

Purpose

To characterize the progression of optical gaps and expand the known etiologies of this phenotype.

Design

Retrospective cohort study.

Methods

Thirty-six patients were selected based on the identification of an optical gap on spectral-domain optical coherence tomography (OCT) from a large cohort of patients (N = 746) with confirmed diagnoses of inherited retinal dystrophy. The width and height of the gaps in 70 eyes of 36 patients were measured by 2 independent graders using the caliper tool on Heidelberg Explorer. Measurements of outer and central retinal thickness were also evaluated and correlated with gap dimensions.

Results

Longitudinal analysis confirmed the progressive nature of optical gaps in patients with Stargardt disease, achromatopsia, occul

SUBMITTER: Oh JK 

PROVIDER: S-EPMC8291221 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature