The early detection of immunoglobulins via optical-based lateral flow immunoassay platform in COVID-19 pandemic.

ABSTRACT: The coronavirus disease (COVID-19) is the global public health challenge currently persisting at a grand scale. A method that meets the rapid quantitative detection of antibodies to assess the body's immune response from natural COVID-19 illness or vaccines' effects is urgently needed. In the present study, an attempt was made to integrate a newly designed spectrometer to the COVID-19 test strip procedure; this augmentation provides the quantitative capacity to a lateral flow immunoassay (LFIA). Optical interpretation of results by quantitative α index, rather than visual qualification, can be done quickly, in 5-10 minutes. The developed product was compared with several other serological IgM/IgG antibody reagents on the market by recruiting 111 participants suspected of having COVID-19 in

SUBMITTER: Chen PY 

PROVIDER: S-EPMC8291656 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature