Impact of IgG response to malaria-specific antigens and immunity against malaria in pre-school children in Ghana. A cluster randomized, placebo-controlled trial.

ABSTRACT:

Background

Iron fortification and micronutrient initiatives, specifically, vitamin A, and zinc supplementation are the most cost-effective developmental strategies against malnutrition and health emergencies in pre-school children. Iron-deficiency among pre-school children have been documented, however, studies evaluating the impact of immunoglobulin G (IgG) isotype responses among iron-fortified pre-school children in malaria endemic communities has not been assessed. We evaluated the impact of iron fortification on the IgG responses to GLURP R0, GLURP R2 and MSP3 FVO malaria-specific antigens among pre-school children in malaria endemic areas.

Methods

This community-based, placebo-controlled, double-blinded, cluster-randomized trial study was conducted in Wenchi Municipal

SUBMITTER: Tchum SK 

PROVIDER: S-EPMC8291688 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature