A CURE Biochemistry Laboratory Module to Study Protein-Protein Interactions by NMR Spectroscopy.

ABSTRACT: Design of undergraduate laboratory courses that provide meaningful research-based experiences enhance undergraduate curricula and prepare future graduate students for research careers. In this article, a Course-based Undergraduate Research Experience (CURE) laboratory module was designed for upper-division undergraduate biochemistry and chemistry students. The laboratory module enabled students to build upon recently published data in the literature to decipher atomistic insight for an essential protein-protein interaction in human biology through the use of biomolecular NMR spectroscopy. Students compared their results with published data with the goal of identifying specific regions of the protein-protein interaction responsible for triggering an allosteric conformational change. The lab

SUBMITTER: Marsiglia WM 

PROVIDER: S-EPMC8291728 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature