Histone-fold centromere protein W (CENP-W) is associated with the biological behavior of hepatocellular carcinoma cells.

ABSTRACT: Centromere protein W (CENP-W), identified as a centromeric component, plays an important role in the cell life cycle. However, how CENPW expression affects biological processes in liver cancer cells remains unknown. In this article, we found that CENPW was overexpressed in liver cancer tissues. Low CENPW expression was correlated with a better prognosis in hepatocellular carcinoma (HCC) patients, compared to high CENPW expression. The results of qRT-PCR and western blot assay showed that CENPW was effectively knocked down in HCC cells using siRNA transfection. Cell proliferation, migration, and invasion were inhibited. Cell apoptosis rates were increased. The cells were arrested in the G2/M phase of the cell cycle. Subsequently, 127 differentially express

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC8291794 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature