CDH11 Regulates Adhesion and Transcellular Migration of Tongue Squamous Cell Carcinoma.

ABSTRACT:

Purpose

CDH11, as a member of cadherins, mediates homotypic cell adhesion. Some studies have shown that CDH11 plays an important role in the development of tumors, especially in the processes of tumor invasion and metastasis. While features of CDH11 in tongue squamous cell carcinoma (TSCC) are still indeterminate, the purpose of the present study is to explore the role of CDH11 in TSCC.

Methods

The expression of cadherin gene in a TSCC cell line with high metastatic potential (LN4) and the parental CAL27 were examined both in the TCGA database and in collected clinical samples, further verified by quantitative real-time PCR. The effects of CDH11 on the proliferation, apoptosis, migration, invasion and adhesion were tested in appropriate ways after CDH11 was overexpressed in

SUBMITTER: Zheng BT 

PROVIDER: S-EPMC8291966 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature