M⁶A mRNA Methylation Regulates Epithelial Innate Antimicrobial Defense Against Cryptosporidial Infection.

ABSTRACT: Increasing evidence supports that N6-methyladenosine (m⁶A) mRNA modification may play an important role in regulating immune responses. Intestinal epithelial cells orchestrate gastrointestinal mucosal innate defense to microbial infection, but underlying mechanisms are still not fully understood. In this study, we present data demonstrating significant alterations in the topology of host m⁶A mRNA methylome in intestinal epithelial cells following infection by Cryptosporidium parvum, a coccidian parasite that infects the gastrointestinal epithelium and causes a self-limited disease in immunocompetent individuals but a life-threatening diarrheal disease in AIDS patients. Altered m⁶A methylation in mRNAs in intestinal epithelial cells following C. pa

SUBMITTER: Xia Z 

PROVIDER: S-EPMC8291979 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature