A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS-Driven Lung Cancer.

ABSTRACT: Cancer genotyping has identified a large number of putative tumor suppressor genes. Carcinogenesis is a multistep process, but the importance and specific roles of many of these genes during tumor initiation, growth, and progression remain unknown. Here we use a multiplexed mouse model of oncogenic KRAS-driven lung cancer to quantify the impact of 48 known and putative tumor suppressor genes on diverse aspects of carcinogenesis at an unprecedented scale and resolution. We uncover many previously understudied functional tumor suppressors that constrain cancer in vivo. Inactivation of some genes substantially increased growth, whereas the inactivation of others increases tumor initiation and/or the emergence of exceptionally large tumors. These functional in vivo analyses revea

SUBMITTER: Cai H 

PROVIDER: S-EPMC8292166 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature