Association between Circulating Protein C Levels and Incident Dementia: The Atherosclerosis Risk in Communities Study.

ABSTRACT:

Introduction

Hemostasis depends on the delicate balance between coagulants and anticoagulants. Higher levels of circulating coagulants have been associated with higher risk of cerebral infarctions and dementia. In contrast, higher levels of circulating protein C, an endogenous anticoagulant, have been associated with lower risk of cerebral infarctions, and the association between protein C levels and the risk of dementia is unknown. The goal of this study was to evaluate the association of circulating protein C levels in midlife and late life with incident dementia.

Methods

Circulating protein C levels were measured using blood samples collected at the midlife baseline (1987-1989) and the late-life baseline (2011-2013) among 14,462 and 3,614 participants, respectively, in th

SUBMITTER: Tin A 

PROVIDER: S-EPMC8292178 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature