Dataset Information

Organophosphate pesticides and progression of chronic kidney disease among children: A prospective cohort study.

ABSTRACT:

Background

Growing evidence suggests that exposure to environmental chemicals, such as pesticides, impacts renal function and chronic kidney disease (CKD). However, it is not clear if pesticides may affect CKD progression and no studies exist in children.

Objectives

The objective of this study was to examine associations between serially measured urinary OP pesticide metabolites and clinical and laboratory measures of kidney function over time among children with CKD.

Methods

This study used data on 618 participants enrolled in the CKD in Children study (CKiD), a cohort study of pediatric CKD patients from the US and Canada. Children were followed over an average of 3.0 years (standard deviation (SD) = 1.6) between 2005 and 2015. In serially collected urine samples over time, six nonspecific dialkyl phosphate (DAP) metabolites of OP pesticides were measured. Biomarkers of tubular injury (kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL)) and oxidant stress (8-hydroxy-2'-deoxyguanosine (8-OHdG) and F₂-isoprostane) were determined in the same specimens. Estimated glomerular filtration rate (eGFR), proteinuria, and blood pressure were assessed annually.

Results

DAPs were associated with increased KIM-1 and 8-OHdG throughout follow-up. A standard deviation increase in ∑diethyl metabolites was associated with increases of 11.9% (95% Confidence Interval (CI): 4.8%, 19.4%) and 13.2% (95% CI: 9.3%, 17.2%) in KIM-1 and 8-OHdG over time, respectively. DAPs were associated with lower eGFR at baseline and higher eGFR over subsequent years.

Conclusions

These findings provide preliminary evidence suggesting that urinary DAP metabolites are associated with subclinical kidney injury among children with CKD, which may signal the potential for clinical events to manifest in the future. The results from this study are significant from both a clinical and public health perspective, given that OP pesticide exposure is a modifiable risk factor.

SUBMITTER: Jacobson MH

PROVIDER: S-EPMC8292180 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

Organophosphate pesticides and progression of chronic kidney disease among children: A prospective cohort study.

Jacobson Melanie H MH Wu Yinxiang Y Liu Mengling M Kannan Kurunthachalam K Li Adela Jing AJ Robinson Morgan M Warady Bradley A BA Furth Susan S Trachtman Howard H Trasande Leonardo L

Environment international 20210502

<h4>Background</h4>Growing evidence suggests that exposure to environmental chemicals, such as pesticides, impacts renal function and chronic kidney disease (CKD). However, it is not clear if pesticides may affect CKD progression and no studies exist in children.<h4>Objectives</h4>The objective of this study was to examine associations between serially measured urinary OP pesticide metabolites and clinical and laboratory measures of kidney function over time among children with CKD.<h4>Methods</ ...[more]

PMID: 33951537

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Dataset Information

Organophosphate pesticides and progression of chronic kidney disease among children: A prospective cohort study.

Background

Objectives

Methods

Results

Conclusions

Publications

Organophosphate pesticides and progression of chronic kidney disease among children: A prospective cohort study.

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