Principles of Alternating Access in Multidrug and Toxin Extrusion (MATE) Transporters.

ABSTRACT: The multidrug and toxin extrusion (MATE) transporters catalyze active efflux of a broad range of chemically- and structurally-diverse compounds including antimicrobials and chemotherapeutics, thus contributing to multidrug resistance in pathogenic bacteria and cancers. Multiple methodological approaches have been taken to investigate the structural basis of energy transduction and substrate translocation in MATE transporters. Crystal structures representing members from all three MATE subfamilies have been interpreted within the context of an alternating access mechanism that postulates occupation of distinct structural intermediates in a conformational cycle powered by electrochemical ion gradients. Here we review the structural biology of MATE transporters, integrating the crystallograph

SUBMITTER: Claxton DP 

PROVIDER: S-EPMC8292195 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature