Molecular Mechanism of Nramp-Family Transition Metal Transport.

ABSTRACT: The Natural resistance-associated macrophage protein (Nramp) family of transition metal transporters enables uptake and trafficking of essential micronutrients that all organisms must acquire to survive. Two decades after Nramps were identified as proton-driven, voltage-dependent secondary transporters, multiple Nramp crystal structures have begun to illustrate the fine details of the transport process and provide a new framework for understanding a wealth of preexisting biochemical data. Here we review the relevant literature pertaining to Nramps' biological roles and especially their conserved molecular mechanism, including our updated understanding of conformational change, metal binding and transport, substrate selectivity, proton transport, proton-metal coupling, and voltage dependenc

SUBMITTER: Bozzi AT 

PROVIDER: S-EPMC8292206 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature