Periconception air pollution, metabolomic biomarkers, and fertility among women undergoing assisted reproduction.

ABSTRACT:

Background

Air pollution exposure has been linked with diminished fertility. Identifying the metabolic changes induced by periconception air pollution exposure among women could enhance our understanding of the potential biological pathways underlying air pollution's reproductive toxicity.

Objective

To identify serum metabolites associated with periconception air pollution exposure and evaluate the extent to which these metabolites mediate the association between air pollution and live birth.

Methods

We included 200 women undergoing a fresh assisted reproductive technology (ART) cycle at Massachusetts General Hospital Fertility Center (2005-2015). A serum sample was collected during stimulation, and untargeted metabolic profiling was conducted using liquid chromatogra

SUBMITTER: Gaskins AJ 

PROVIDER: S-EPMC8292230 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature