Tolerance to neurochemical and behavioral effects of the hallucinogen 25I-NBOMe.

ABSTRACT:

Rationale

4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25I-NBOMe) is a potent serotonin 5-HT_2A/2C receptor agonist with hallucinogenic activity. There is no data on the 25I-NBOMe effect on brain neurotransmission and animal performance after chronic administration.

Objectives

We examined the effect of a 7-day treatment with 25I-NBOMe (0.3 mg/kg/day) on neurotransmitters' release and rats' behavior in comparison to acute dose.

Methods

Changes in dopamine (DA), serotonin (5-HT), acetylcholine (ACh), and glutamate release were studied using microdialysis in freely moving rats. The hallucinogenic activity was measured in the wet dog shake (WDS) test. The animal locomotion was examined in the open field (OF) test, short-term memory in the novel object

SUBMITTER: Herian M 

PROVIDER: S-EPMC8292280 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature