Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass.

ABSTRACT: Menopause is associated with a redistribution of adipose tissue towards central adiposity, known to cause insulin resistance. In this cross-sectional study of 33 women between 45 and 60 years, we assessed adipose tissue inflammation and morphology in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) across menopause and related this to menopausal differences in adipose tissue distribution and insulin resistance. We collected paired SAT and VAT biopsies from all women and combined this with anthropometric measurements and estimated whole-body insulin sensitivity. We found that menopause was associated with changes in adipose tissue phenotype related to metabolic dysfunction. In SAT, postmenopausal women showed adipocyte hypertrophy, increased inflammation, hypoxia and fibr

SUBMITTER: Abildgaard J 

PROVIDER: S-EPMC8292317 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature