Multi-omics integration of methyltransferase-like protein family reveals clinical outcomes and functional signatures in human cancer.

ABSTRACT: Human methyltransferase-like (METTL) proteins transfer methyl groups to nucleic acids, proteins, lipids, and other small molecules, subsequently playing important roles in various cellular processes. In this study, we performed integrated genomic, transcriptomic, proteomic, and clinicopathological analyses of 34 METTLs in a large cohort of primary tumor and cell line data. We identified a subset of METTL genes, notably METTL1, METTL7B, and NTMT1, with high frequencies of genomic amplification and/or up-regulation at both the mRNA and protein levels in a spectrum of human cancers. Higher METTL1 expression was associated with high-grade tumors and poor disease prognosis. Loss-of-function analysis in tumor cell lines indicated the biological importance of METTL1, an m⁷G methyltrans

SUBMITTER: Campeanu IJ 

PROVIDER: S-EPMC8292347 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature