Predicting critical state after COVID-19 diagnosis: model development using a large US electronic health record dataset.

ABSTRACT: As the COVID-19 pandemic is challenging healthcare systems worldwide, early identification of patients with a high risk of complication is crucial. We present a prognostic model predicting critical state within 28 days following COVID-19 diagnosis trained on data from US electronic health records (IBM Explorys), including demographics, comorbidities, symptoms, and hospitalization. Out of 15753 COVID-19 patients, 2050 went into critical state or deceased. Non-random train-test splits by time were repeated 100 times and led to a ROC AUC of 0.861 [0.838, 0.883] and a precision-recall AUC of 0.434 [0.414, 0.485] (median and interquartile range). The interpretability analysis confirmed evidence on major risk factors (e.g., older age, higher BMI, male gender, diabetes, and cardiovascular disease

SUBMITTER: Rinderknecht MD 

PROVIDER: S-EPMC8292360 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature