Diminished reward responsiveness is associated with lower reward network GluCEST: an ultra-high field glutamate imaging study.

ABSTRACT: Low reward responsiveness (RR) is associated with poor psychological well-being, psychiatric disorder risk, and psychotropic treatment resistance. Functional MRI studies have reported decreased activity within the brain's reward network in individuals with RR deficits, however the neurochemistry underlying network hypofunction in those with low RR remains unclear. This study employed ultra-high field glutamate chemical exchange saturation transfer (GluCEST) imaging to investigate the hypothesis that glutamatergic deficits within the reward network contribute to low RR. GluCEST images were acquired at 7.0 T from 45 participants (ages 15-29, 30 females) including 15 healthy individuals, 11 with depression, and 19 with psychosis spectrum symptoms. The GluCEST contrast, a measure sensitive to

SUBMITTER: Sydnor VJ 

PROVIDER: S-EPMC8292427 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature