Neurodevelopmental outcomes following neonatal late-onset sepsis and blood culture-negative conditions.

ABSTRACT:

Objective

Determine risk of death or neurodevelopmental impairment (NDI) in infants with late-onset sepsis (LOS) versus late-onset, antibiotic-treated, blood culture-negative conditions (LOCNC).

Design

Retrospective cohort study.

Setting

24 neonatal centres.

Patients

Infants born 1/1/2006-31/12/2014, at 22-26 weeks gestation, with birth weight 401-1000 g and surviving >7 days were included. Infants with early-onset sepsis, necrotising enterocolitis, intestinal perforation or both LOS and LOCNC were excluded.

Exposures

LOS and LOCNC were defined as antibiotic administration for ≥5 days with and without a positive blood/cerebrospinal fluid culture, respectively. Infants with these diagnoses were also compared with infants with neither condition.

Outcome

SUBMITTER: Mukhopadhyay S 

PROVIDER: S-EPMC8292446 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature