Characterization of point-spread function specification error on Geometric Transfer Matrix partial volume correction in [¹¹C]PiB amyloid imaging.

ABSTRACT:

Purpose

Partial-volume correction (PVC) using the Geometric Transfer Matrix (GTM) method is used in positron emission tomography (PET) to compensate for the effects of spatial resolution on quantitation. We evaluate the effect of misspecification of scanner point-spread function (PSF) on GTM results in amyloid imaging, including the effect on amyloid status classification (positive or negative).

Methods

Twenty-nine subjects with Pittsburgh Compound B ([¹¹C]PiB) PET and structural T1 MR imaging were analyzed. FreeSurfer 5.3 (FS) was used to parcellate MR images into regions-of-interest (ROIs) that were used to extract radioactivity concentration values from the PET images. GTM PVC was performed using our "standard" PSF parameterization [3D Gaussian, full-width at h

SUBMITTER: Laymon CM 

PROVIDER: S-EPMC8292473 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature