Functional avoidance-based intensity modulated proton therapy with 4DCT derived ventilation imaging for lung cancer.

ABSTRACT: The primary objective is to evaluate the potential dosimetric gains of performing functional avoidance-based proton treatment planning using 4DCT derived ventilation imaging. 4DCT data of 31 patients from a prospective functional avoidance clinical trial were evaluated with intensity modulated proton therapy (IMPT) plans and compared with clinical volumetric modulated arc therapy (VMAT) plans. Dosimetric parameters were compared between standard and functional plans with IMPT and VMAT with one-way analysis of variance and post hoc paired student t-test. Normal Tissue Complication Probability (NTCP) models were employed to estimate the risk of two toxicity endpoints for healthy lung tissues. Dose degradation due to proton motion interplay effect was evaluated. Functional IMPT plans led to s

SUBMITTER: Dougherty JM 

PROVIDER: S-EPMC8292710 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature