The β₂-Subunit of Voltage-Gated Calcium Channels Regulates Cardiomyocyte Hypertrophy.

ABSTRACT: L-type voltage-gated calcium channels (LTCCs) regulate crucial physiological processes in the heart. They are composed of the Ca_vα₁ pore-forming subunit and the accessory subunits Ca_vβ, Ca_vα₂δ, and Ca_vγ. Ca_vβ is a cytosolic protein that regulates channel trafficking and activity, but it also exerts other LTCC-independent functions. Cardiac hypertrophy, a relevant risk factor for the development of congestive heart failure, depends on the activation of calcium-dependent pro-hypertrophic signaling cascades. Here, by using shRNA-mediated Ca_vβ silencing, we demonstrate that Ca_vβ₂ downregulation enhances α1-adrenergic receptor agonist-induced cardiomyocyte hypertrophy. We report that a

SUBMITTER: Pickel S 

PROVIDER: S-EPMC8292724 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature