Reversal of alopecia areata, osteoporosis follow treatment with activation of Tgr5 in mice.

ABSTRACT:

Background

Alopecia areata is an autoimmune hair loss disease with infiltration of pro-inflammatory cells into hair follicles. The role of Tgr5 in dermatitis has attracted considerable attention. The present study aimed to investigate the effect of Tgr5 in the development of Alopecia areata.

Methods

The study utilized a comparison control group design with four groups of wild-type group, wild-type+INT777 group, Tgr5-/- group, and Tgr5-/-+INT777 group. The mice were treated with INT777 (30 mg/kg/day) or the carrier solution (DMSO) intraperitoneally for 7 weeks, and the back skin was collected and analyzed by histology and immunohistochemistry staining. The lumbar vertebrae 4 has also been analyzed by DXA and Micro-CT.

Results

Tgr5-/- mice displayed the decreasingly sig

SUBMITTER: Zhou X 

PROVIDER: S-EPMC8292761 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature