Reporting of adverse events, conflict of interest and funding in randomised controlled trials of antibiotics: a secondary analysis.

ABSTRACT:

Objectives

Transparent reporting of trials is necessary to assess their internal and external validity. Currently, little is known about the quality of reporting in antibiotics trials. Our study investigates the reporting of adverse events, conflicts of interest and funding information in trials of penicillins, cephalosporins and macrolides.

Design

A secondary analysis of trials included in a convenience sample of three systematic reviews.

Methods

All randomised controlled trials included in the systematic reviews were included, although duplicates were removed. Eligible trials compared the specified antibiotics to placebo, for any indication. Author pairs independently extracted the data on reporting of adverse events from parent reviews, and data on funding and conf

SUBMITTER: Bakhit M 

PROVIDER: S-EPMC8292799 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature