Cu-Ferrocene-Functionalized CaO₂ Nanoparticles to Enable Tumor-Specific Synergistic Therapy with GSH Depletion and Calcium Overload.

ABSTRACT: The conversion of endogenous H₂ O₂ into toxic hydroxyl radical (^• OH) via catalytic nanoparticles is explored for tumor therapy and received considerable success. The intrinsic characteristics of microenvironment in tumor cells, such as limited H₂ O₂ and overexpressed glutathione (GSH), hinder the intracellular ^• OH accumulation and thus weaken therapeutic efficacy considerably. In this study, fine CaO₂ nanoparticles with Cu-ferrocene molecules at the surface (CaO₂ /Cu-ferrocene) are successfully designed and synthesized. Under an acidic condition, the particles release Ca²⁺ ions and H₂ O₂ in a rapid fashion, while they can remain stable in neutral. In addition, agitated

SUBMITTER: Kong H 

PROVIDER: S-EPMC8292872 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature