A Lab-On-chip Tool for Rapid, Quantitative, and Stage-selective Diagnosis of Malaria.

ABSTRACT: Malaria remains the most important mosquito-borne infectious disease worldwide, with 229 million new cases and 409.000 deaths in 2019. The infection is caused by a protozoan parasite which attacks red blood cells by feeding on hemoglobin and transforming it into hemozoin. Despite the WHO recommendation of prompt malaria diagnosis, the quality of microscopy-based diagnosis is frequently inadequate while rapid diagnostic tests based on antigens are not quantitative and still affected by non-negligible false negative/positive results. PCR-based methods are highly performant but still not widely used in endemic areas. Here, a diagnostic tool (TMek), based on the paramagnetic properties of hemozoin nanocrystals in infected red blood cells (i-RBCs), is reported on. Exploiting the competition bet

SUBMITTER: Giacometti M 

PROVIDER: S-EPMC8292881 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature